GK040 ScienCell 人成纖維細胞生長因子信號通路qPCR檢測試劑盒,Human Fibroblast Growth Factor Signaling Pathway qPCR Array Kit

ScienCell 研究實驗室（ScienCell）是一家生物技術公司，其使命是實驗和治療用細胞和細胞相關產(chǎn)品的研究和發(fā)展。 ScienCell為研究界提供各種高質(zhì)量的正常的人類和動物細胞，細胞培養(yǎng)基和試劑，培養(yǎng)基添加因子，細胞來源的RNA，cDNA和蛋白質(zhì)。ScienCell的科學家們以改善生活質(zhì)量，實現(xiàn)細胞的能力，打擊人類退化性疾病為目的研究和開發(fā)各種細胞治療策略。ScienCell總部設在美國加利福尼亞州圣地亞哥，公司成立于1999年。

北京諾博萊德作為ScienCell品牌的經(jīng)銷商，為客戶提供，正規(guī)進口，貨期穩(wěn)定，折扣好的服務標準。

GK040 ScienCell人成纖維細胞生長因子信號通路qPCR檢測試劑盒，Human Fibroblast Growth Factor Signaling Pathway qPCR Array Kit，產(chǎn)品簡介：

產(chǎn)品品牌: ScienCell

產(chǎn)品貨號：GK040

產(chǎn)品名稱：GK040 ScienCell人成纖維細胞生長因子信號通路qPCR檢測試劑盒，Human Fibroblast Growth Factor Signaling Pathway qPCR Array Kit

產(chǎn)品規(guī)格：One 96-well plate, one 20ul reaction per well

GK040 ScienCell人成纖維細胞生長因子信號通路qPCR檢測試劑盒，Human Fibroblast Growth Factor Signaling Pathway qPCR Array Kit， 產(chǎn)品說明：

ScienCell 的 GeneQuery™ 人成纖維細胞生長因子信號通路 qPCR 陣列試劑盒 （GQH-FGF） 旨在促進成纖維細胞生長因子 （FGF） 信號通路中涉及的 88 個關鍵基因的基因表達譜分析。FGF參與多種生物學功能，如胚胎發(fā)育、器官發(fā)生、血管生成、組織再生和傷口愈合。通過與FGF受體（FGFR）的結合，FGF激活和調(diào)節(jié)許多下游信號通路，如MAPK，JNK和STAT/NF-κB。如何根據(jù)其功能對所包含的基因進行分組的簡要示例如下所示：  

分泌性 FGF

FGF1超家族：FGF1，FGF2

FGF4超家族：FGF4、FGF5

FGF7超家族：FGF3，FGF7，FGF10

FGF8超家族：FGF17、FGF18

FGF9超家族：FGF9，FGF16，FGF20

內(nèi)分泌 FGF： FGF19， FGF23

細胞內(nèi)FGFs：FGF13，FGF14

FGF受體：FGFR1，FGFR2，FGFR3，FGFR5

FGF信號抑制劑：IL17RD，SPRY2，SPRY4，PTPN1，DUSP1，DUSP6

激活的下游途徑

MAPK通路：FRS2，GAB1，SOS1，PTPN11，SHC1，RAS，BRAF，MAPK1，MAPK3，MAP2K1，MAP2K2

PI3K/AKT 途徑： AKT1， AKT2， AKT3， PI3Ks， FOXO1， FOXO3， BAD， BAX， CASP9

JNK途徑： MAPK8， MAPK9， MAPK14， RAC1， ATF2， MAP2K4， MAP2K6

STAT/NF-κB 途徑： STAT1， STAT3， NFKB1， NFKB2， REL， MMP9

GeneQuery™ qPCR 芯片試劑盒采用 96 孔板格式的 qPCR 就緒，每個孔包含一個引物組，可以特異性識別并有效擴增靶基因的 cDNA。精心設計的引物確保：（i）qPCR分析中的優(yōu)良退火溫度為65°C（含2 mM Mg2+，不含DMSO）;（ii）除非另有說明，否則引物組可識別靶基因的所有已知轉(zhuǎn)錄本變體;（iii）只有一個基因被擴增。每個引物組都已通過qPCR和熔解曲線分析和凝膠電泳進行了驗證。

ScienCell's GeneQuery™ Human Fibroblast Growth Factor Signaling Pathway qPCR Array Kit (GQH-FGF) is designed to facilitate gene expression profiling of 88 key genes involved in Fibroblast Growth Factor (FGF) signaling pathways. FGFs are involved in a wide variety of biological functions such as embryonic development, organogenesis, angiogenesis, tissue regeneration and wound healing. Through their binding with FGF receptors (FGFRs), FGFs activate and regulate many downstream signaling pathways, such as MAPK, JNK and STAT/NF-κB. Brief examples of how included genes may be grouped according to their functions are shown below:    

·         Secreted FGFs

o    FGF1 superfamily: FGF1, FGF2

o    FGF4 superfamily: FGF4, FGF5

o    FGF7 superfamily: FGF3, FGF7, FGF10

o    FGF8 superfamily: FGF17, FGF18

o    FGF9 superfamily: FGF9, FGF16, FGF20

·         Endocrine FGFs: FGF19, FGF23

·         Intracellular FGFs: FGF13, FGF14

·         FGF receptors: FGFR1, FGFR2, FGFR3, FGFR5

·         FGF signaling inhibitors: IL17RD, SPRY2, SPRY4, PTPN1, DUSP1, DUSP6

·         Activated downstream pathways

o    MAPK pathway: FRS2, GAB1, SOS1, PTPN11, SHC1, RAS, BRAF, MAPK1, MAPK3, MAP2K1, MAP2K2

o    PI3K/AKT pathway: AKT1, AKT2, AKT3, PI3Ks, FOXO1, FOXO3, BAD, BAX, CASP9

o    JNK pathway: MAPK8, MAPK9, MAPK14, RAC1, ATF2, MAP2K4, MAP2K6

o    STAT/NF-κB pathway: STAT1, STAT3, NFKB1, NFKB2, REL, MMP9

GeneQuery™ qPCR array kits are qPCR ready in a 96-well plate format, with each well containing one primer set that can specifically recognize and efficiently amplify a target gene's cDNA. The carefully designed primers ensure that: (i) the optimal annealing temperature in qPCR analysis is 65°C (with 2 mM Mg2+, and no DMSO); (ii) the primer set recognizes all known transcript variants of target gene, unless otherwise indicated; and (iii) only one gene is amplified. Each primer set has been validated by qPCR with melt curve analysis, and gel electrophoresis.

基因查詢™人成纖維細胞生長因子信號通路qPCR陣列板布局*（8 個粗體和斜體控件）

提示：基因選擇可能會根據(jù)新的研究和開發(fā)進行更新

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